Shi Xiao-yun, Wu Fang-rong, Chen Shi-ling, Wang Qing-ling, Luo Chen, Ni Yun-ping, Zheng Hai-yan, Qiu Zhuo-lin, Zhang Wei-qing, Yang Jie, Chen Xin
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Oct;30(10):2263-6.
To evaluate the clinical outcomes of intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF) using sibling oocytes for treatment of primary and secondary infertility.
A total of 149 cycles of IVF and ICSI were conducted between January, 2003 and December, 2008 in our center, including 98 cycles in patients with primary infertility and 51 in those with secondary infertility. According to the embryos derived from ICSI, IVF and their combination, the clinical pregnancy rate, delivery rate and birth defect of the 3 groups were analyzed.
The fertilization failure rate of IVF was significantly higher in primary infertility group than in secondary infertility group (10.2% vs 3.9%, P<0.05). No fertilization failure occurred in ICSI group. The fertilization rates and good quality embryo rates in ICSI group were significant higher than those in IVF group, and the abnormal fertilization rate was significantly lower in ICSI group (P<0.05). No significant difference were found in the implantation rates, clinical pregnancy rates, delivery rates or the rates of birth defects of the offsprings between IVF, ICSI and IVF+ICSI groups.
IVF combined with ICSI may result in increased fertilization rate and avoid total fertilization failure with favorable clinical outcomes in patients with long-term infertility, and ICSI may not increase the birth defects of the offspring in these patients.
评估卵胞浆内单精子注射（ICSI）与常规体外受精（IVF）利用同胞卵母细胞治疗原发性和继发性不孕症的临床结局。
2003年1月至2008年12月在本中心共进行了149个IVF和ICSI周期，其中原发性不孕症患者98个周期，继发性不孕症患者51个周期。根据ICSI、IVF及其联合产生的胚胎，分析三组的临床妊娠率、分娩率和出生缺陷情况。
原发性不孕症组IVF的受精失败率显著高于继发性不孕症组（10.2%对3.9%，P<0.05）。ICSI组未发生受精失败。ICSI组的受精率和优质胚胎率显著高于IVF组，且ICSI组的异常受精率显著更低（P<0.05）。IVF组、ICSI组和IVF+ICSI组在植入率、临床妊娠率、分娩率或后代出生缺陷率方面未发现显著差异。
IVF联合ICSI可能提高受精率并避免完全受精失败，对长期不孕症患者有良好的临床结局，且ICSI可能不会增加这些患者后代的出生缺陷。
