Haque A K, Mancuso M G, Hokanson J, Nguyen N D, Nichols M M
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
Pediatr Pathol. 1991 Jul-Aug;11(4):551-68. doi: 10.3109/15513819109064790.
Sudden infant death syndrome (SIDS) infants have significantly thicker and more cellular bronchiolar walls than control infants of similar age. A morphometric study of 25 SIDS and 18 control infants was undertaken to measure the bronchiolar wall thickness using a Cue-2 image analysis system. A mathematical formula (relative index) was used to compare the thickness of bronchioles of varying diameter. Data analysis using a nested design two-way analysis of variance and covariance of the measured bronchioles showed a significant difference between the SIDS and control infants with a P value less than .001. Manual counting of the cells in the bronchiolar walls and data analysis using an unpaired two-tailed t test showed that the SIDS infants had a significantly greater number of cells than control infants (P less than .01). Our preliminary results indicate that the cells in the bronchiolar wall are either peripheral nerve-derived (Schwann cells) or Langerhans cells. We postulate that these cells are increased in number in response to chronic hypoxia in SIDS infants.
与同龄对照婴儿相比，婴儿猝死综合征（SIDS）患儿的细支气管壁明显更厚且细胞更多。对25例SIDS患儿和18例对照婴儿进行了一项形态计量学研究，使用Cue-2图像分析系统测量细支气管壁厚度。采用数学公式（相对指数）比较不同直径细支气管的厚度。对测量的细支气管进行嵌套设计的双向方差分析和协方差分析，数据分析显示SIDS患儿和对照婴儿之间存在显著差异，P值小于0.001。对细支气管壁细胞进行手动计数，并使用不成对双尾t检验进行数据分析，结果显示SIDS患儿的细胞数量明显多于对照婴儿（P小于0.01）。我们的初步结果表明，细支气管壁中的细胞要么是外周神经源性的（施万细胞），要么是朗格汉斯细胞。我们推测，这些细胞的数量在SIDS患儿中因慢性缺氧而增加。
