[Allogeneic lymphocytic cytotoxicity].

Allogeneic lymphocyte cytotoxicity (ALC) is identified in vivo by injecting radiolabeled lymphocytes into syngeneic and allogeneic animals and comparing the distribution of radioactivity in several body compartments, usually 6 hr after injection in both types of host. Destruction of the labeled cells in allogeneic recipients is associated with the reduction in radioactivity recovered from the lymph nodes and lungs and increase in the radioactivity in plasma, kidney and urine. The mechanism of the ALC is reviewed.