Drannik G N, Baran E Ia, Seniuk O F, Driianskaia V E
Fiziol Zh (1978). 1989 Sep-Oct;35(5):68-72.
It is supposed that determination of antibody-dependent cellular-mediated cytotoxicity and spontaneous cellular-mediated cytotoxicity in the peripheral blood is non-informative for early diagnosis of acute rejection crisis. Activity of K- and NK-cells in peripheral blood is observed to increase during a peak of the rejection crisis. While studying cellular infiltrate obtained from the transplanted kidney, activity of K- and NK-cells is shown to considerably increase in the rejected transplants, which can testify that they contribute much in the loss of the allotransplant function.
据推测，外周血中抗体依赖性细胞介导的细胞毒性和自发性细胞介导的细胞毒性的测定对急性排斥反应危机的早期诊断并无参考价值。在排斥反应危机高峰期，观察到外周血中K细胞和NK细胞的活性增加。在研究从移植肾获取的细胞浸润时发现，在发生排斥反应的移植肾中，K细胞和NK细胞的活性显著增加，这可以证明它们在同种异体移植功能丧失中起了很大作用。
