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颈动脉内膜切除术在治疗效果及适宜性方面的种族和民族差异:患者及医疗服务提供者因素的影响。

Racial and ethnic disparities in outcomes and appropriateness of carotid endarterectomy: impact of patient and provider factors.

作者信息

Halm Ethan A, Tuhrim Stanley, Wang Jason J, Rojas Mary, Rockman Caron, Riles Thomas S, Chassin Mark R

机构信息

Division of General Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8889, USA.

出版信息

Stroke. 2009 Jul;40(7):2493-501. doi: 10.1161/STROKEAHA.108.544866. Epub 2009 May 21.

Abstract

BACKGROUND AND PURPOSE

Prior work documented racial and ethnic disparities in incidence of stroke, stroke risk factors, and use of carotid endarterectomy. Less is known about disparities in outcomes and appropriateness of carotid endarterectomy or reasons for such inequalities.

METHODS

This was a population-based cohort of carotid endarterectomy performed in Medicare beneficiaries in New York. Clinical data were abstracted from medical charts to assess sociodemographics, clinical indication for carotid endarterectomy, disease severity, comorbidities, and deaths and strokes within 30 days of surgery. Appropriateness was based on validated criteria from a national expert panel. Differences in patients, providers, outcomes, and appropriateness were compared using chi(2) tests. Differences in risk-adjusted rates of death or nonfatal stroke were compared using multiple logistic regression accounting for patient, physician, and hospital-level risk factors.

RESULTS

Overall, 95.3% of patients undergoing carotid endarterectomy were white, 2.5% black, and 2.2% Hispanic (N=9093). Minorities had more severe neurological disease and more comorbidities and were more likely to be cared for by lower-volume surgeons and hospitals (P<0.0001). Rates of 30-day death/stroke were higher in Hispanics (9.5%) and blacks (6.9%) than whites (3.8%; P<0.0001). Multivariable analyses that adjusted for presurgical patient risk and provider characteristics found that blacks no longer had significantly worse outcomes (OR=1.37; CI, 0.78 to 2.40), although the higher risk of death/stroke in Hispanics persisted (OR=1.87; CI, 1.09 to 3.19). Minorities had higher rates of inappropriate surgery (Hispanics 17.6%, black 13.0%, white 7.9%; P<0.0001) largely due to higher comorbidity.

CONCLUSIONS

Minorities had worse outcomes and higher rates of inappropriate surgery. Differences in underlying presurgical risk factors and provider characteristics explained the higher risk of complications in blacks, but not Hispanics.

摘要

背景与目的

先前的研究记录了中风发病率、中风危险因素以及颈动脉内膜切除术使用方面的种族和民族差异。关于颈动脉内膜切除术的结果和适宜性差异或此类不平等的原因,人们了解较少。

方法

这是一项基于纽约医疗保险受益人的颈动脉内膜切除术人群队列研究。从病历中提取临床数据,以评估社会人口统计学、颈动脉内膜切除术的临床指征、疾病严重程度、合并症以及手术30天内的死亡和中风情况。适宜性基于国家专家小组的验证标准。使用卡方检验比较患者、医疗服务提供者、结果和适宜性方面的差异。使用多因素逻辑回归分析比较死亡或非致命性中风的风险调整率,该分析考虑了患者、医生和医院层面的风险因素。

结果

总体而言,接受颈动脉内膜切除术的患者中,95.3%为白人,2.5%为黑人,2.2%为西班牙裔(N = 9093)。少数族裔的神经疾病更严重,合并症更多,并且更有可能由手术量较少的外科医生和医院进行治疗(P < 0.0001)。西班牙裔(9.5%)和黑人(6.9%)的30天死亡/中风发生率高于白人(3.8%;P < 0.0001)。在对术前患者风险和医疗服务提供者特征进行调整的多变量分析中发现,黑人的结果不再显著更差(OR = 1.37;CI,0.78至2.40),尽管西班牙裔死亡/中风的较高风险仍然存在(OR = 1.87;CI,1.09至3.19)。少数族裔的不适当手术发生率较高(西班牙裔17.6%,黑人13.0%,白人7.9%;P < 0.0001),这主要是由于合并症较多。

结论

少数族裔的结果更差,不适当手术发生率更高。术前潜在风险因素和医疗服务提供者特征的差异解释了黑人并发症风险较高的原因,但无法解释西班牙裔的情况。

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