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[1例晚期胃癌伴多发肝转移患者接受S-1与顺铂联合治疗后完全缓解(CR)持续3年3个月的病例]

[A case of complete response (CR) persisting for 3 years and 3 months from combination therapy of S-1 and CDDP in a patient with advanced gastric cancer with multiple liver metastases].

作者信息

Sekino Yasushi, Okada Masao, Hamada Joji, Tagami Soichi, Sakon Masahiro, Okita Kouichi, Takata Manabu, Seki Hitoshi, Hayashi Ken, Munakata Yasuhiro

机构信息

Dept. of Surgery, Nagano Municipal Hospital.

出版信息

Gan To Kagaku Ryoho. 2009 May;36(5):847-9.

Abstract

The case was a 70-year-old man with type-2 gastric cancer in the lesser curvature accompanied by multiple liver metastases. He received combination chemotherapy of S-1 and CDDP. S-1 was administered at 100 mg/body/day for 21 days followed by withdrawal for 14 days, and CDDP was prescribed at 80 mg/body/day div on day 8. After 3 courses of treatment, the multiple liver metastases disappeared. The primary gastric lesion had changed to a scar and endoscopic biopsy revealed no cancer cell. After the 4th course, we changed the therapy to S-1 alone and after that to UFT alone. Now, 3 years and 3 months after inducing CR, the patient continues to receive UFT with no regrowth of the tumor.

摘要

该病例为一名70岁男性,患有胃小弯处的2型胃癌并伴有多处肝转移。他接受了S-1和顺铂的联合化疗。S-1按100mg/体/天给药,持续21天,随后停药14天,顺铂在第8天按80mg/体/天分剂量给药。经过3个疗程的治疗,多处肝转移消失。原发性胃病变已变为瘢痕,内镜活检未发现癌细胞。第4个疗程后,我们将治疗方案改为单独使用S-1,之后又改为单独使用优福定。现在,在达到完全缓解3年零3个月后,患者继续接受优福定治疗,肿瘤未再生长。

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