Lee C, Barnes A, Yang E, Katz R L
Br J Anaesth. 1977 Jun;49(6):555-60. doi: 10.1093/bja/49.6.555.
The compound electromyographic response of the thenar musculature was elicited by supramaximal stimulation of the ulnar nerve in 12 awake healthy volunteers. The half-refractory period of the neuromuscular transmission was determined. Twin stimuli separated by the half-refractory interval were repeated as a unit at 2 Hz and at 50 Hz. Thus two trains of responses, one beginning with a maximal response, the other with a half-maximal response, were obtained with each frequently of stimulation. Marked facilitation of the electromyographic response began with the train of stimulation, especially with tetanic stimulation. A secondary fade occurred occasionally. These changes were more remarkable in the train of half-refractory responses. We conclude that nerve stimulation facilitates neuromuscular transmission and deduce that the characteristic fade observed with a curariform block, rather than being an uncovered physiological phenomenon, is caused by tubocurarine and related drugs.
在12名清醒的健康志愿者中，通过对尺神经进行超强刺激引出大鱼际肌的复合肌电图反应。测定神经肌肉传递的半不应期。以半不应期为间隔分开的双次刺激作为一个单元，分别以2Hz和50Hz的频率重复。因此，在每个刺激频率下，都获得了两串反应，一串从最大反应开始，另一串从半最大反应开始。肌电图反应的明显易化从刺激串开始，尤其是强直刺激时。偶尔会出现继发性衰减。这些变化在半不应期反应串中更为明显。我们得出结论，神经刺激可促进神经肌肉传递，并推断箭毒样阻滞时观察到的特征性衰减，并非未被发现的生理现象，而是由筒箭毒碱及相关药物引起的。
