通过施陶丁格连接实现脂质体的化学选择性表面糖基功能化。
Chemically-selective surface glyco-functionalization of liposomes through Staudinger ligation.
作者信息
Zhang Hailong, Ma Yong, Sun Xue-Long
机构信息
Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
出版信息
Chem Commun (Camb). 2009 Jun 7(21):3032-4. doi: 10.1039/b822420j. Epub 2009 Apr 28.
DOI:10.1039/b822420j
PMID:19462077
Abstract
An efficient and chemoselective liposome surface glyco-functionalization method has been developed based on Staudinger ligation, in which the carbohydrate derivative carrying an azide spacer is conjugated onto the surface of preformed liposomes bearing a terminal triphosphine in PBS buffer (pH 7.4) at room temperature.
摘要
基于施陶丁格连接反应，已开发出一种高效且具有化学选择性的脂质体表面糖基功能化方法，即在室温下，于pH 7.4的磷酸盐缓冲盐溶液（PBS）中，将带有叠氮间隔基的碳水化合物衍生物与带有末端三膦的预制脂质体表面进行共轭连接。
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