Ziada Amal M
Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Muscat, Sultanate of Oman.
J Hypertens. 2009 Jun;27(6):1309-16. doi: 10.1097/hjh.0b013e328329fb55.
To investigate whether the combination of exercise training with the angiotensin-converting enzyme inhibitor lisinopril will have an additional beneficial effect on left ventricular function in spontaneously hypertensive rats.
Twelve-week-old male rats were assigned to treadmill running (Ht-Ex; 20 m/min at 5 degrees grade, 1 h/day, 5 days/week), or lisinopril treatment (Ht-Lis; 15 mg/kg per day by gavage), or treadmill running while treated with lisinopril (Ht-ExLis), and were compared with a sedentary group (Ht-Sed). Age-matched and sex-matched Wistar-Kyoto rats were controls.
After 10 weeks of experimentation, left ventricular morphology and function were assessed from M-mode echocardiograms and transmitral Doppler spectra [early (E) and atrial peak velocities (A), their ratio (E/A), and E-wave deceleration time (Edec time) and slope (Edec slope)].
Ht-Sed exhibited prominent concentric left ventricular hypertrophy with systolic and diastolic dysfunctions evidenced by a significantly reduced fractional shortening (%FS) and 'pseudonormalization' of left ventricular filling, characterized by an apparently normal E/A ratio despite an underlying left ventricular relaxation abnormality. Exercise training did not significantly alter left ventricular morphology or function. Lisinopril alone attenuated left ventricular hypertrophy and enhanced diastolic function but had no significant effect on systolic function. Combining exercise training with lisinopril treatment increased %FS by 25%, decreased the E/A ratio and Edec slope by 35% and 37%, respectively, and increased Edec time by 82%.
Our results provide experimental evidence that lisinopril administration, when combined with moderate exercise training, is more promising in attenuating cardiac dysfunction than either agent alone in hypertension of a genetic origin.
研究运动训练与血管紧张素转换酶抑制剂赖诺普利联合使用是否会对自发性高血压大鼠的左心室功能产生额外的有益影响。
将12周龄雄性大鼠分为三组，分别进行跑步机跑步训练（Ht-Ex组；速度为20米/分钟，坡度为5度，每天1小时，每周5天），或给予赖诺普利治疗（Ht-Lis组；每天经口灌胃15毫克/千克），或在给予赖诺普利治疗的同时进行跑步机跑步训练（Ht-ExLis组），并与久坐不动组（Ht-Sed组）进行比较。年龄和性别匹配的Wistar-Kyoto大鼠作为对照。
实验10周后，通过M型超声心动图和二尖瓣多普勒频谱[早期（E）和心房峰值速度（A）、它们的比值（E/A）、E波减速时间（Edec时间）和斜率（Edec斜率）]评估左心室形态和功能。
Ht-Sed组表现出明显的同心性左心室肥厚，伴有收缩和舒张功能障碍，表现为缩短分数（%FS）显著降低以及左心室充盈的“假性正常化”，其特征是尽管存在潜在的左心室舒张异常，但E/A比值明显正常。运动训练未显著改变左心室形态或功能。单独使用赖诺普利可减轻左心室肥厚并增强舒张功能，但对收缩功能无显著影响。运动训练与赖诺普利治疗相结合使%FS增加了25%，E/A比值和Edec斜率分别降低了3
