Ali Badreldin H, Karaca Turan, Al Suleimani Yousuf, Al Za'abi Mohammed, Al Kalbani Jamila, Ashique Mohammed, Nemmar Abderrahim
Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman.
Department of Histology-Embryology, Faculty of Medicine, University of Trakya, Balkan Campus, Edirne, Turkey.
PLoS One. 2017 Apr 26;12(4):e0176316. doi: 10.1371/journal.pone.0176316. eCollection 2017.
Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25% w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents' curcumin or lisinopril might offer additional nephroprotection.
据报道，慢性肾脏病（CKD）患者可从不同类型的运动中获益。研究还表明，血管紧张素转换酶抑制剂赖诺普利以及天然产物姜黄素在大鼠CKD的不同模型中也具有益处。我们评估了适度游泳运动（SE）对腺嘌呤诱导的CKD大鼠的影响，并使用多种生理、生化、组织病理学和免疫组化参数测试了赖诺普利和/或姜黄素对其可能产生的作用。将大鼠（久坐不动或进行SE）随机分为几组，连续五周给予正常食物或与腺嘌呤（0.25% w/w）混合的食物以诱导CKD。其中一些组还同时口服姜黄素（75 mg/kg）或赖诺普利（10 mg/kg），并进行适度SE（每周三天，每天45分钟）。喂食腺嘌呤的大鼠表现出CKD典型的生化和组织病理学特征，如血压升高、尿白蛋白/肌酐比值升高以及血浆尿素、肌酐、硫酸吲哚酚和磷升高。单独给予SE、姜黄素或赖诺普利均能显著改善所有腺嘌呤诱导的症状。将姜黄素或赖诺普利与SE联合使用可改善肾脏的组织病理学，这是单独使用SE时未观察到的有益效果。将SE与肾保护剂姜黄素或赖诺普利联合使用可能会提供额外的肾脏保护作用。
