Shaw L M, George P R, Oldham A A, Heagerty A M
Department of Medicine, Manchester Royal Infirmary, UK.
J Hypertens. 1995 Oct;13(10):1135-43. doi: 10.1097/00004872-199510000-00008.
To investigate whether, when angiotensin converting enzyme inhibitors are administered to young, genetically hypertension-prone animals, the demonstrated attenuation of blood pressure development and prevention of the structural changes usually observed in small arteries is attributable to the prevention of angiotensin II production.
We have treated spontaneously hypertensive rats (SHR) aged 4-20 weeks with either lisinopril (1 or 10 mg/kg) or the angiotensin II receptor antagonist D 8731 (1, 20 or 50 mg/kg).
Blood pressure was measured and structural parameters in small arteries from four vascular beds were examined using isometric myography.
At age 20 weeks lisinopril had attenuated blood pressure development and prevented cardiac hypertrophy (but not vascular hypertrophy) in a dose-dependent manner. The highest dose of lisinopril had reduced the blood pressure of the SHR to below that of the Wistar-Kyoto (WKY) rats and prevented most structural changes, but there was a slight reduction in body weight in those rats. Comparable blood pressure control with D 8731 was associated with similar structural parameters.
The prevention of hypertension-associated vascular structural alteration appears to be dependent upon the degree of blood pressure control.
研究当给年轻的、具有遗传易患高血压的动物使用血管紧张素转换酶抑制剂时，所显示的血压升高的减轻以及小动脉中通常观察到的结构变化的预防是否归因于血管紧张素II生成的预防。
我们用赖诺普利（1或10毫克/千克）或血管紧张素II受体拮抗剂D 8731（1、20或50毫克/千克）治疗了4至20周龄的自发性高血压大鼠（SHR）。
测量血压，并使用等长肌动描记法检查来自四个血管床的小动脉的结构参数。
在20周龄时，赖诺普利以剂量依赖的方式减轻了血压升高并预防了心脏肥大（但未预防血管肥大）。赖诺普利的最高剂量已将SHR的血压降低至低于Wistar-Kyoto（WKY）大鼠的血压，并预防了大多数结构变化，但这些大鼠的体重略有减轻。D 8731的类似血压控制与相似的结构参数相关。
高血压相关血管结构改变的预防似乎取决于血压控制的程度。
