Osaka Kimito, Kobayashi Masataka, Takano Tetsuzou, Tsuchiya Futoshi, Iwasaki Akira, Ishizuka Eiichi, Nagashima Yoji
Department of Urology, Yokohama City Minato Red Cross Hospital.
Hinyokika Kiyo. 2009 Apr;55(4):223-7.
We report two cases of granulocyte-colony stimulating factor (G-CSF) producing infiltrating urothelial carcinoma of the kidney. Case 1: A 58-year-old woman was referred to our hospital for fever and right back pain. Blood test showed severe inflammation and computed tomographic (CT) scan demonstrated swelling and irregular enhancement of the right kidney. Under the diagnosis of pyonephrosis or renal tumor, we performed right radical nephrectomy. The patient died of lung and liver metastases 6 months postoperatively despite of adjuvant chemotherapy. Case 2: A 76-year-old woman was referred to our hospital for a chief complaint of gross hematuria. Retrograde pyelogram and CT scan demonstrated a right renal pelvic tumor and we performed right nephroureterectomy. The patient died of liver and lung metastases 4 months postoperatively. The pathological and histochemical findings of these two cases were G-CSF producing infiltrating transitional cell carcinoma of the kidney. They showed marked leukocytosis and elevation of serum G-CSF levels. To our knowledge, they are the first two cases of G-CSF producing infiltrating urothelial carcinoma of the kidney in Japanese literature.
我们报告了两例产生粒细胞集落刺激因子（G-CSF）的浸润性肾尿路上皮癌病例。病例1：一名58岁女性因发热和右背部疼痛转诊至我院。血液检查显示严重炎症，计算机断层扫描（CT）显示右肾肿胀且强化不规则。在诊断为肾盂积脓或肾肿瘤后，我们进行了右肾根治性切除术。尽管进行了辅助化疗，患者术后6个月死于肺和肝转移。病例2：一名76岁女性因肉眼血尿为主诉转诊至我院。逆行肾盂造影和CT扫描显示右肾盂肿瘤，我们进行了右肾输尿管切除术。患者术后4个月死于肝和肺转移。这两例病例的病理和组织化学检查结果均为产生G-CSF的浸润性肾移行细胞癌。它们表现出明显白细胞增多和血清G-CSF水平升高。据我们所知，它们是日本文献中首例两例产生G-CSF的浸润性肾尿路上皮癌病例。
