Carrillo-Carrión Carolina, Cárdenas Soledad, Simonet Bartolomé M, Valcárcel Miguel
Department of Analytical Chemistry, University of Córdoba, E-14071 Córdoba, Spain.
Anal Chem. 2009 Jun 15;81(12):4730-3. doi: 10.1021/ac900034h.
We report the first observation of selective and specific recognition of chiral L-cysteine (L-Cys)- or D-cysteine (D-Cys)-capped CdSe(ZnS) quantum dots (QDs) with carnitine enantiomers in aqueous solution. The intensity fluorescence of L-Cys-capped QDs decay in the presence of D-carnitine but are not affected by L-carnitine. On the other hand, the fluorescence of D-Cys-capped QDs was only affected by L-carnitine. The applicability of chiral Cys-capped QDs for the analysis of chiral mixtures on enantiomers has been demonstrated for 1:100 mixtures, and the results that were obtained had high precision (<2.3%) and low error (<2.7%).
我们首次报道了在水溶液中肉碱对映体对手性L-半胱氨酸（L-Cys）或D-半胱氨酸（D-Cys）包覆的CdSe(ZnS)量子点（QDs）的选择性和特异性识别。L-Cys包覆的量子点的荧光强度在D-肉碱存在下衰减，但不受L-肉碱影响。另一方面，D-Cys包覆的量子点的荧光仅受L-肉碱影响。手性半胱氨酸包覆的量子点用于对映体手性混合物分析的适用性已在1:100混合物中得到证明，所获得的结果具有高精度（<2.3%）和低误差（<2.7%）。
