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健康差异中的A、G、C和T

The A's, G's, C's, and T's of health disparities.

作者信息

Ramos Edward, Rotimi Charles

机构信息

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Bethesda, MD 20892-5635, USA.

出版信息

BMC Med Genomics. 2009 May 22;2:29. doi: 10.1186/1755-8794-2-29.

Abstract

In order to eliminate health disparities in the United States, more efforts are needed to address the breadth of social issues directly contributing to the healthy divide observed across racial and ethnic groups. Socioeconomic status, education, and the environment are intimately linked to health outcomes. However, with the tremendous advances in technology and increased investigation into human genetic variation, genomics is poised to play a valuable role in bolstering efforts to find new treatments and preventions for chronic conditions and diseases that disparately affect certain ethnic groups. Promising studies focused on understanding the genetic underpinnings of diseases such as prostate cancer or beta-blocker treatments for heart failure are illustrative of the positive contribution that genomics can have on improving minority health.

摘要

为了消除美国的健康差距,需要做出更多努力来解决那些直接导致不同种族和族裔群体间健康差异的广泛社会问题。社会经济地位、教育和环境与健康结果密切相关。然而,随着技术的巨大进步以及对人类基因变异研究的增加,基因组学有望在加强寻找新治疗方法和预防措施的努力中发挥重要作用,这些新方法和预防措施旨在应对对某些族裔群体有不同程度影响的慢性病和疾病。专注于理解前列腺癌等疾病的遗传基础或心力衰竭的β受体阻滞剂治疗的有前景的研究,说明了基因组学在改善少数族裔健康方面所能做出的积极贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d600/2698907/38595207691f/1755-8794-2-29-1.jpg

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