Allon Dror M, Anavi Yakir, Calderon Shlomo
Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jun;107(6):811-8. doi: 10.1016/j.tripleo.2009.02.013.
The aim was to evaluate the effectiveness of the long-term administration of intranasal calcitonin spray for the treatment of central giant cell granuloma (CGCG) in a retrospective case study.
The medical files of 5 patients (4 male, 1 female; ages 8-66 years) with CGCG of the jaws treated with calcitonin nasal spray 200 U/spray once or twice daily were reviewed for lesion-related parameters, outcome, and adverse effects of therapy.
Three lesions were located in the mandibular body and ramus region and 2 in the anterior maxilla. Mean lesion size on radiography was 3.2 x 2.3 cm. The duration of calcitonin treatment was 9-60 months (mean 28 months). All the lesions considerably decreased in size with a high degree of calcification. There were no recurrences.
Calcitonin nasal spray appears to be safe and effective for the treatment of CGCG and might be considered an alternative to surgery. Further controlled studies are needed to corroborate these findings.
在一项回顾性病例研究中，评估长期使用鼻内降钙素喷雾剂治疗中央型巨细胞肉芽肿（CGCG）的有效性。
回顾了5例（4例男性，1例女性；年龄8 - 66岁）颌骨CGCG患者的病历，这些患者接受了每日一次或两次、每次200 U/喷的降钙素鼻喷雾剂治疗，记录病变相关参数、治疗结果及不良反应。
3处病变位于下颌体和升支区域，2处位于上颌前部。X线片上病变平均大小为3.2×2.3 cm。降钙素治疗持续时间为9 - 60个月（平均28个月）。所有病变大小均显著减小，且钙化程度高。无复发情况。
降钙素鼻喷雾剂治疗CGCG似乎安全有效，可作为手术的替代方法。需要进一步的对照研究来证实这些发现。
