de Lange J, Rosenberg A J, van den Akker H P, Koole R, Wirds J J, van den Berg H
Department of Oral and Maxillofacial Surgery, Academic Medical Center/Academic Center for Dentistry, Amsterdam, The Netherlands.
Int J Oral Maxillofac Surg. 1999 Oct;28(5):372-6. doi: 10.1034/j.1399-0020.1999.285280513.x.
Giant cell granuloma of the jaw is a benign lesion that may cause local destruction of bone and displacement of teeth. The common therapy is curettage or resection, which may be associated with loss of teeth and, in younger patients, loss of dental germs. An alternative treatment has recently been introduced, in which patients receive a daily dose of calcitonin. Four patients who have been treated with calcitonin in various concentrations for at least 1 year are reported. In all patients, complete remission of the giant cell granuloma was observed, without signs of recurrence. The working mechanism of calcitonin is discussed, as are length of treatment and optimal dose.
颌骨巨细胞肉芽肿是一种良性病变，可导致局部骨质破坏和牙齿移位。常用的治疗方法是刮除术或切除术，这可能会导致牙齿缺失，对于年轻患者，还可能导致牙胚缺失。最近引入了一种替代治疗方法，即患者每日服用降钙素。本文报告了4例接受不同浓度降钙素治疗至少1年的患者。所有患者的巨细胞肉芽肿均完全缓解，无复发迹象。文中讨论了降钙素的作用机制、治疗时长和最佳剂量。
