Headington J T, Batsakis J G, Beals T F, Campbell T E, Simmons J L, Stone W D
Cancer. 1977 Jun;39(6):2460-9. doi: 10.1002/1097-0142(197706)39:6<2460::aid-cncr2820390624>3.0.co;2-6.
A basal cell adenoma of parotid, eccrine dermal cylindromas and trichoepitheliomas occurring in the same patient were examined by light and electron microscopy and histochemistry. The eccrine and parotid adenomas were similar both structurally and histochemically except for the presence of Langerhans cells in the cutaneous adenoma and well differentiated mucinous cells in the parotid tumor. The three different hamartomas found in this individual may represent the effect of a single pleiotropic gene acting on ontogenetically related stem cells.
对同一患者发生的腮腺基底细胞腺瘤、小汗腺真皮圆柱瘤和毛发上皮瘤进行了光镜、电镜及组织化学检查。除皮肤腺瘤中存在朗格汉斯细胞以及腮腺肿瘤中有分化良好的黏液细胞外，小汗腺腺瘤和腮腺腺瘤在结构和组织化学方面均相似。在该个体中发现的三种不同错构瘤可能代表了一个单一的多效基因作用于个体发育相关干细胞的效应。
