脑血管疾病患者的载脂蛋白E基因型及其对疾病转归的影响。

Apolipoprotein E genotype in patients with cerebrovascular diseases and its effect on the disease outcome.

作者信息

Tamam Yusuf, Tasdemir Nebahat, Toprak Recep, Tamam Banu, Iltumur Kenan

机构信息

Department of Neurology, Medical School Dicle University, Diyarbakir, Turkey.

出版信息

Int J Neurosci. 2009;119(7):919-35. doi: 10.1080/00207450802686350.

DOI:10.1080/00207450802686350

PMID:19466630

Abstract

A total of 100 hospitalized stroke patients and 30 healthy controls were included in a study aiming to determine the predictive role of ApoE genotype polymorphism for stroke outcome in the Turkish population. The most frequent ApoE genotype was epsilon3/3 reflecting Asian population polymorphic distribution. ApoE polymorphism in the Eastern Turkish population was found to be independent of stroke type, OSCP subtypes of infarction, localization of hemorrhage, severity of carotid artery stenosis, and resultant stroke outcome. Distinct polymorphic results in populations from nearby regions suggest a multifactorial pathogenesis and presence of very complex genetic factors in the development of stroke and stroke outcome.

摘要

一项研究纳入了100名住院中风患者和30名健康对照者，旨在确定载脂蛋白E（ApoE）基因多态性对土耳其人群中风预后的预测作用。最常见的ApoE基因型是ε3/3，反映了亚洲人群的多态性分布。研究发现，土耳其东部人群的ApoE多态性与中风类型、梗死的腔隙性脑梗塞亚型、出血部位、颈动脉狭窄程度以及中风预后无关。邻近地区人群不同的多态性结果表明，中风及其预后的发生存在多因素发病机制和非常复杂的遗传因素。