Tascilar N, Dursun A, Ankarali H, Mungan G, Sumbuloglu V, Ekem S, Bozdogan S, Baris S, Aciman E, Cabuk F
Department of Neurology, Zonguldak Karaelmas University Medical Faculty, Zonguldak, Turkey.
J Neurol Sci. 2009 Feb 15;277(1-2):17-21. doi: 10.1016/j.jns.2008.09.034. Epub 2008 Oct 21.
Apolipoprotein E (apoE) polymorphism is suggested to be a risk factor in stroke in some populations, either by affecting lipid parameters or independently. Its effect on lipoprotein(a) [Lp(a)] is not known. The roles of apoE polymorphism and of high Lp(a) levels in atherosclerotic stroke (AS) in the Turkish population are unclear. Our aim was to investigate the relationship of apoE alleles and Lp(a) level with AS and the relationship of apoE alleles with Lp(a) and other lipid parameters.
ApoE polymorphisms and lipid parameters were prospectively evaluated in 85 patients and 77 controls with normal brain imaging.
Only hypertension, diabetes mellitus, associated vascular diseases and decreased high-density lipoprotein cholesterol levels were found to be independent risk factors for stroke. However, in the presence of apoE/E4 allele, increased low-density lipoprotein cholesterol (LDL-chol), apolipoprotein B (apoB) and Lp(a) levels and in the presence of apo E/E3 allele, only Lp(a) levels were determined as risk factors.
This study showed that while apoE polymorphism was not a risk factor itself, high Lp(a), LDL-chol and apoB were determined to be risk factors in E3 or E4 carriers.
载脂蛋白E（apoE）多态性被认为是某些人群中风的一个危险因素，其作用机制可能是通过影响脂质参数，也可能是独立起作用。但其对脂蛋白(a) [Lp(a)]的影响尚不清楚。在土耳其人群中，apoE多态性和高Lp(a)水平在动脉粥样硬化性中风（AS）中的作用尚不清楚。我们的目的是研究apoE等位基因和Lp(a)水平与AS的关系，以及apoE等位基因与Lp(a)和其他脂质参数的关系。
对85例患者和77例脑成像正常的对照者进行前瞻性评估，检测其apoE多态性和脂质参数。
仅发现高血压、糖尿病、相关血管疾病和高密度脂蛋白胆固醇水平降低是中风的独立危险因素。然而，在存在apoE/E4等位基因时，低密度脂蛋白胆固醇（LDL-chol）、载脂蛋白B（apoB）和Lp(a)水平升高；在存在apo E/E3等位基因时，仅Lp(a)水平被确定为危险因素。
本研究表明，虽然apoE多态性本身不是危险因素，但在E3或E4携带者中，高Lp(a)、LDL-chol和apoB被确定为危险因素。
