Li F P, McIntosh S, Peng-Whang J
Cancer. 1977 Jun;39(6):2633-6. doi: 10.1002/1097-0142(197706)39:6<2633::aid-cncr2820390649>3.0.co;2-e.
Two brothers developed multiple primary neoplasms in childhood; one had glioblastoma and non-Hodgkin's lymphoma at age 11 years, and the other brain tumor and acute leukemia at six years. A third brother died with myelogenous leukemia at thre years, and a fourth with cyanotic congenital heart disease at 11 weeks. Each child also had at least one hamartomatous lesion of the skin. The clinical features suggested von Recklinghausen's neurofibromatosis or other inherited cancer syndrome, but laboratory studies identified no markers of susceptibility to familial neoplasia.
两兄弟在童年时期患上了多种原发性肿瘤；一个在11岁时患了胶质母细胞瘤和非霍奇金淋巴瘤，另一个在6岁时患了脑肿瘤和急性白血病。第三个兄弟在3岁时死于骨髓性白血病，第四个在11周时死于青紫型先天性心脏病。每个孩子还至少有一处皮肤错构瘤性病变。临床特征提示为冯·雷克林豪森神经纤维瘤病或其他遗传性癌症综合征，但实验室检查未发现家族性肿瘤易感性的标志物。
