Kao Shou-Yen, Chu Yu-Wei, Chen Ya-Wei, Chang Kuo-Wei, Liu Tsung-Yun
Department of Stomatology, Taipei Veterans General Hospital, Taiwan, R.O.C.
J Chin Med Assoc. 2009 May;72(5):227-33. doi: 10.1016/s1726-4901(09)70062-0.
Oral cancer is a fatal disease, accounting for the fourth highest incidence of malignancy in males and the seventh in females in Taiwan. The relatively high prevalence of oral cancer in Taiwan is mainly because there is a high-risk group of 2.5 million people with the habit of smoking and betel nut chewing. Unfortunately, 50% of new cases in our medical center who present with TNM stage III or IV lesions have a shorter than 5-year survival after treatment. This highlights the need for: (1) early treatment of fresh oral cancer cases; (2) screening of the high-risk population to detect new lesions; (3) careful follow-up of cases after treatment; and (4) detection of occult early neck nodal adenopathy in surgical cases. It is generally accepted that prevention and screening of oral cancer are equally important to treatment due to its location. In this review article, we describe the nature of oral cancer and highlight the various conventional and novel methods of screening for this disease and ongoing important related research. Related literature is reviewed and future work that needs to be done is detailed.
口腔癌是一种致命疾病，在台湾男性恶性肿瘤发病率中排第四，女性中排第七。台湾口腔癌患病率相对较高，主要是因为有250万吸烟和嚼槟榔习惯的高危人群。不幸的是，在我们医疗中心就诊的TNM III期或IV期病变的新病例中，50%在治疗后的生存期不足5年。这凸显了以下需求：（1）早期治疗新的口腔癌病例；（2）筛查高危人群以发现新病变；（3）仔细随访治疗后的病例；（4）在手术病例中检测隐匿性早期颈部淋巴结病变。由于口腔癌的发病部位，人们普遍认为其预防和筛查与治疗同样重要。在这篇综述文章中，我们描述了口腔癌的本质，强调了针对这种疾病的各种传统和新型筛查方法以及正在进行的重要相关研究。对相关文献进行了综述，并详细说明了未来需要开展的工作。
