El-Radaideh Khaled M
King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Rev Bras Anestesiol. 2007 Feb;57(1):32-8. doi: 10.1590/s0034-70942007000100004.
Performed a randomized, double blind study to assess the efficacy of intravenous (IV) pretreatment with lidocaine, IV paracetamol (Perfalgan) or lidocaine mixed with fentanyl in reducing propofol injection pain.
Immediately after venous occlusion with a rubber tourniquet on the patient's arm IV lidocaine 1% 4 mL (Group L, n = 50), IV paracetamol (Perfalgan) 4 mL (40 mg) (Group R, n = 50), lidocaine 2% mixed with 100 microg fentanyl (Group LF, n = 50) or normal saline 4 mL (Group P, n = 50; as placebo control) was given to 200 adult patients. The release of the venous occlusion was done after 60s and followed by intravenous administration of propofol 2.5 mg kg(-1) at rate of 0.5 mg s(-1) through a 20G catheter inserted in hand dorsum vein. Pain assessment was made during the propofol injection. This included movement of hand, spontaneous verbal expressions of pain, frowning, and moaning during the injection of propofol.
Lidocaine-fentanyl (70% pain free), and lidocaine (68% pain free) significantly reduced propofol injection pain more than paracetamol (54% pain free) and more than placebo (36% pain free) (p < 0.05). The difference in reducing the incidence of propofol injection pain between lidocaine and lidocaine-fentanyl did not reach statistical significance. There was a significant superiority of paracetamol compared to placebo (p < 0.05).
Propofol, a commonly used anesthetic. Given as a venous retention pretreatment 60 seconds before propofol, lidocaine and lidocaine-fentanyl were found to significantly reduce the propofol injection pain, whereas IV paracetamol (Perfalgan) slightly reduced the propofol injection pain.
开展一项随机双盲研究，以评估静脉注射利多卡因、静脉注射对乙酰氨基酚（必理通）或利多卡因与芬太尼混合使用在减轻丙泊酚注射痛方面的疗效。
在患者手臂上用橡胶止血带进行静脉阻断后，立即给200名成年患者静脉注射1%利多卡因4毫升（L组，n = 50）、静脉注射对乙酰氨基酚（必理通）4毫升（40毫克）（R组，n = 50）、2%利多卡因与100微克芬太尼混合液（LF组，n = 50）或4毫升生理盐水（P组，n = 50；作为安慰剂对照）。60秒后松开静脉阻断，然后通过插入手背静脉的20G导管以0.5毫克/秒的速度静脉注射2.5毫克/千克丙泊酚。在丙泊酚注射期间进行疼痛评估。这包括注射丙泊酚期间手部的动作、疼痛的自发言语表达、皱眉和呻吟。
利多卡因 - 芬太尼组（70%无痛）和利多卡因组（68%无痛）比扑热息痛组（54%无痛）和安慰剂组（36%无痛）更能显著减轻丙泊酚注射痛（p < 0.05）。利多卡因和利多卡因 - 芬太尼在降低丙泊酚注射痛发生率方面的差异未达到统计学意义。对乙酰氨基酚组与安慰剂组相比有显著优势（p < 0.05）。
丙泊酚是一种常用麻醉剂。在丙泊酚给药前60秒作为静脉留置预处理，发现利多卡因和利多卡因 - 芬太尼能显著减轻丙泊酚注射痛，而静脉注射对乙酰氨基酚（必理通）能轻微减轻丙泊酚注射痛。
