Seki M, Yoshida K, Nishimura M, Nemoto K
Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.
Radiat Res. 1991 Aug;127(2):146-9.
We found that the incidence of spontaneous myeloid leukemia in C3H/He male mice was less than 1%, but it could be increased considerably by total-body X irradiation. The induction of myeloid leukemia was seen to increase after doses from 0.47 Gy (3%) to 2.84 Gy (23.9%), and then decrease after a dose of 4.73 Gy (13.6%). The administration of prednisolone acetate (synthesized glucocorticoid) after irradiation resulted in a significant increase in the incidence of myeloid leukemia from 23.9 to 38.5% after a dose of 2.84 Gy; however, corticosterone, a glucocorticoid secreted by cells, did not have such an enhancing effect.
我们发现，C3H/He雄性小鼠自发性髓系白血病的发病率低于1%，但全身X射线照射可使其显著增加。髓系白血病的诱导率在剂量从0.47 Gy（3%）增加到2.84 Gy（23.9%）后上升，然后在剂量为4.73 Gy（13.6%）后下降。照射后给予醋酸泼尼松龙（合成糖皮质激素）导致髓系白血病发病率显著增加，在剂量为2.84 Gy后从23.9%升至38.5%；然而，细胞分泌的糖皮质激素皮质酮并没有这种增强作用。
