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叶仙人掌（仙人掌科）叶片的细胞毒性成分。

Cytotoxic components of Pereskia bleo (Kunth) DC. (Cactaceae) leaves.

作者信息

Malek Sri Nurestri Abdul, Shin Sim Kae, Wahab Norhanom Abdul, Yaacob Hashim

机构信息

Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Molecules. 2009 May 6;14(5):1713-24. doi: 10.3390/molecules14051713.

DOI:10.3390/molecules14051713
PMID:19471192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6254274/
Abstract

Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and beta-sitosterol (4)], together with the previously isolated individual compounds beta-sitosterol (4), 2,4-di-tert-butylphenol (5), alpha-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC(50 )value of 0.81microg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.

摘要

从仙人掌科植物虎刺叶的活性乙酸乙酯部位分离得到了二氢猕猴桃内酯（1）、甾醇混合物[菜油甾醇（2）、豆甾醇（3）和β-谷甾醇（4）]，以及之前分离得到的单一化合物β-谷甾醇（4）、2,4-二叔丁基苯酚（5）、α-生育酚（6）、叶绿醇（7）。研究了上述化合物对五种人类癌细胞系，即人鼻咽表皮样癌细胞系（KB）、人宫颈癌细胞系（CasKi）、人结肠癌细胞系（HCT 116）、人激素依赖性乳腺癌细胞系（MCF7）和人肺癌细胞系（A549），以及非癌人类成纤维细胞系（MRC-5）的细胞毒活性。化合物5对KB细胞具有非常显著的细胞毒活性，IC50值为0.81μg/mL。这是关于从虎刺叶中分离得到的化合物细胞毒活性的首次报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/6254274/607e9c3f051e/molecules-14-01713-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/6254274/607e9c3f051e/molecules-14-01713-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/6254274/607e9c3f051e/molecules-14-01713-g001.jpg

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