Palmowski M, Palmowski M, Hauff P, Kiessling F
Institut für Experimentelle Molekulare Bildgebung, Universitätsklinikum der RWTH, Aachen.
Praxis (Bern 1994). 2009 May 27;98(11):597-602. doi: 10.1024/1661-8157.98.11.597.
Molecular imaging enables to assess disease-associated processes at the cellular and molecular level. Nuclear medicine techniques are already available in the clinical routine. Besides these techniques, intensive research has been performed in the field of ultrasound. The development of target-specific ultrasound contrast agents in combination with modern imaging systems transformed ultrasound to a capable molecular imaging technique. It has been shown that the expression of disease-associated endothelial receptors can be assessed using targeted microbubbles, demonstrating its high value in the diagnosis of several diseases. The broad availability of suitable ultrasound systems promises a wide utilisation in the clinical routine, once clinically approved contrast agents are available. This review summarizes the basics and the current status of molecular ultrasound imaging.
分子成像能够在细胞和分子水平评估与疾病相关的过程。核医学技术已应用于临床常规检查。除了这些技术外，超声领域也进行了深入研究。靶向特异性超声造影剂与现代成像系统的结合，使超声转变为一种有效的分子成像技术。已表明，使用靶向微泡可以评估与疾病相关的内皮受体的表达，这证明了其在多种疾病诊断中的高价值。一旦有临床批准的造影剂，合适的超声系统的广泛可用性有望在临床常规中得到广泛应用。本综述总结了分子超声成像的基础知识和现状。
