Burton Mary Jane, Olivier Jake, Mena Leandro
Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Am J Med Sci. 2009 Jul;338(1):54-6. doi: 10.1097/MAJ.0b013e31819e2ad8.
Injection drug use (IDU) is considered the major risk factor for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection. We examined risk factors for HIV/HCV coinfection in a region with a low reported rate of IDU.
We identified 146 HIV/HCV coinfected patients in Jackson, Mississippi. Medical records were reviewed for demographics, social history, and risk factors for HIV and HCV acquisition. A randomly selected group of HIV-monoinfected patients from the same clinic served as a control group.
History of IDU (P < 0.0001), crack cocaine use (P < 0.0001), incarceration (P < 0.0001), and syphilis (P < 0.0001) were significantly associated with HCV infection in this cohort of HIV patients. However, the reported rate of IDU (32.5%) is lower than other published HIV/HCV-infected cohorts.
HIV/HCV patients in Mississippi are less likely to report a history of IDU than other coinfected populations, suggesting an alternative means of HCV transmission. Further studies are needed to examine the role of syphilis, crack cocaine use, and incarceration as risk factors for HCV infection in this population of HIV patients.
注射吸毒被认为是人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）合并感染的主要危险因素。我们在一个报告的注射吸毒率较低的地区研究了HIV/HCV合并感染的危险因素。
我们在密西西比州杰克逊市确定了146例HIV/HCV合并感染患者。查阅病历以了解人口统计学、社会史以及感染HIV和HCV的危险因素。从同一诊所随机选取一组HIV单一感染患者作为对照组。
在这组HIV患者中，注射吸毒史（P<0.0001）、使用快克可卡因史（P<0.0001）、监禁史（P<0.0001）和梅毒史（P<0.0001）与HCV感染显著相关。然而，报告的注射吸毒率（32.5%）低于其他已发表的HIV/HCV感染队列。
密西西比州的HIV/HCV患者报告注射吸毒史的可能性低于其他合并感染人群，这表明存在HCV传播的其他途径。需要进一步研究以考察梅毒、使用快克可卡因和监禁作为这组HIV患者中HCV感染危险因素的作用。
