Institute for Technical Chemistry, Leibniz University Hannover, Callinstr. 3, 30167, Hannover, Germany,
Adv Biochem Eng Biotechnol. 2009;115:145-69. doi: 10.1007/10_2009_10.
For better control of productivity and product quality, detailed monitoring of various parameters is required. Since disposable bioreactors become more and more important for biotechnological applications, adequate sensors for this type of reactor are necessary. The required properties of sensors used in disposable reactors differ from those of sensors for multiuse reactors. For example, sensors which are in direct contact with the medium must be inexpensive, but do not need a long life-time, since they can be used only once.This chapter gives an overview on the state of the art and future trends in the field of sensors suited for use in disposable bioreactors. The main focus here is on in situ sensors, which can be based on optical, semiconductor and ultrasonic technologies, but current concepts for disposable sampling units are also reviewed.
为了更好地控制生产力和产品质量，需要详细监测各种参数。由于一次性生物反应器在生物技术应用中变得越来越重要，因此这种类型的反应器需要足够的传感器。一次性反应器中使用的传感器所需的特性与多用途反应器中使用的传感器不同。例如，与介质直接接触的传感器必须价格低廉，但不需要很长的使用寿命，因为它们只能使用一次。本章概述了适用于一次性生物反应器的传感器领域的最新技术和未来趋势。这里的主要重点是原位传感器，它可以基于光学、半导体和超声技术，但也回顾了当前用于一次性采样单元的概念。
