酸试验：双孔通道 (TPCs) 作为 NAADP 门控内溶酶体 Ca(2+) 释放通道的发现。
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
机构信息
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
出版信息
Pflugers Arch. 2009 Sep;458(5):869-76. doi: 10.1007/s00424-009-0682-y. Epub 2009 May 28.
Abstract
In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca(2+) mobilisation. In addition, we describe how TPCs may also trigger further Ca(2+) release by coupling to the endoplasmic reticular stores through activation of IP(3) receptors and ryanodine receptors.
摘要
在这篇综述中，我们描述了我们最近的发现的背景和意义，即双孔通道（TPCs）组成了一类新型的钙释放通道，由细胞内信使烟酰胺腺嘌呤二核苷酸磷酸（NAADP）门控。它们定位于内溶酶体系统，突出了这些细胞器作为 NAADP 介导的 Ca2+动员靶点的新功能。此外，我们还描述了 TPCs 如何通过与内质网储存库的连接，通过激活 IP3 受体和 Ryanodine 受体来触发进一步的 Ca2+释放。
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