Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH, USA.
FEBS Lett. 2010 May 17;584(10):1966-74. doi: 10.1016/j.febslet.2010.02.028. Epub 2010 Feb 14.
Two-pore channels (TPCs or TPCNs) are novel members of the large superfamily of voltage-gated cation channels with slightly higher sequence homology to the pore-forming subunits of voltage-gated Ca(2+) and Na(+) channels than most other members. Recent studies demonstrate that TPCs locate to endosomes and lysosomes and form Ca(2+) release channels that respond to activation by the Ca(2+) mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled.
双孔通道（TPCs 或 TPCNs）是电压门控阳离子通道大家族中的新成员，与电压门控 Ca(2+)和 Na(+)通道的孔形成亚基的序列同源性略高于大多数其他成员。最近的研究表明，TPCs 定位于内体和溶酶体，并形成钙释放通道，对钙动员信使烟酰胺腺嘌呤二核苷酸磷酸（NAADP）的激活作出反应。随着多个内溶酶体靶向的 NAADP 受体的鉴定，将揭示有关健康和疾病中内溶酶体功能调节的重要新见解。
