TPCs：内溶酶体通道，可通过 NAADP 触发酸性细胞器中的 Ca2+动员。
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP.
机构信息
Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH, USA.
出版信息
FEBS Lett. 2010 May 17;584(10):1966-74. doi: 10.1016/j.febslet.2010.02.028. Epub 2010 Feb 14.
Abstract
Two-pore channels (TPCs or TPCNs) are novel members of the large superfamily of voltage-gated cation channels with slightly higher sequence homology to the pore-forming subunits of voltage-gated Ca(2+) and Na(+) channels than most other members. Recent studies demonstrate that TPCs locate to endosomes and lysosomes and form Ca(2+) release channels that respond to activation by the Ca(2+) mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled.
摘要
双孔通道（TPCs 或 TPCNs）是电压门控阳离子通道大家族中的新成员，与电压门控 Ca(2+)和 Na(+)通道的孔形成亚基的序列同源性略高于大多数其他成员。最近的研究表明，TPCs 定位于内体和溶酶体，并形成钙释放通道，对钙动员信使烟酰胺腺嘌呤二核苷酸磷酸（NAADP）的激活作出反应。随着多个内溶酶体靶向的 NAADP 受体的鉴定，将揭示有关健康和疾病中内溶酶体功能调节的重要新见解。
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本文引用的文献
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Two-pore channels for integrative Ca signaling.用于整合钙信号传导的双孔通道。
Commun Integr Biol. 2010 Jan;3(1):12-7. doi: 10.4161/cib.3.1.9793.
2
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.纯化的 TPC 同工型形成具有不同 Ca(2+)信号和内溶酶体运输作用的 NAADP 受体。
Curr Biol. 2010 Apr 27;20(8):703-9. doi: 10.1016/j.cub.2010.02.049. Epub 2010 Mar 25.
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Calcium signaling via two-pore channels: local or global, that is the question.双孔通道介导的钙信号：局部还是全局，这是个问题。
Am J Physiol Cell Physiol. 2010 Mar;298(3):C430-41. doi: 10.1152/ajpcell.00475.2009. Epub 2009 Dec 16.
4
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles.一个祖先后口动物双孔通道家族介导烟酰胺腺嘌呤二核苷酸磷酸依赖性酸性细胞器内钙释放。
J Biol Chem. 2010 Jan 29;285(5):2897-901. doi: 10.1074/jbc.C109.081943. Epub 2009 Nov 25.
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Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.双孔通道1在NAADP介导的钙信号传导中的基本要求。
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Second messenger signaling: multiple receptors for NAADP.第二信使信号传导：NAADP的多种受体
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7
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.双孔通道 TPCN2 介导 NAADP 依赖性溶酶体储存钙释放。
Pflugers Arch. 2009 Sep;458(5):891-9. doi: 10.1007/s00424-009-0690-y. Epub 2009 Jun 26.
8
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.酸试验：双孔通道 (TPCs) 作为 NAADP 门控内溶酶体 Ca(2+) 释放通道的发现。
Pflugers Arch. 2009 Sep;458(5):869-76. doi: 10.1007/s00424-009-0682-y. Epub 2009 May 28.
9
NAADP mobilizes calcium from acidic organelles through two-pore channels.烟酰胺腺嘌呤二核苷酸磷酸（NAADP）通过双孔通道从酸性细胞器中动员钙。
Nature. 2009 May 28;459(7246):596-600. doi: 10.1038/nature08030. Epub 2009 Apr 22.
10
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.1型尼曼-匹克病是一种鞘氨醇贮积病，可导致溶酶体钙调节异常。
Nat Med. 2008 Nov;14(11):1247-55. doi: 10.1038/nm.1876. Epub 2008 Oct 26.
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