Institute for Health Economics and Health Care Management at Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg (by Munich), Germany.
Inflamm Bowel Dis. 2010 Jan;16(1):42-51. doi: 10.1002/ibd.20989.
The EuroQol (EQ)-5D questionnaire is a generic instrument measuring health-related quality of life. Its validity, reliability, and responsiveness were assessed in a large sample of Crohn's disease (CD) and ulcerative colitis (UC) patients.
The EQ-5D was completed initially (270 CD and 232 UC subjects) and after 4 weeks (447 subjects) with a transition question rating health change. Responsiveness of EQ visual analog scale (EQ-VAS) and the United Kingdom (UK-index) and German EQ-5D index (EQ-index) scores to reported changes in health was evaluated by standardized response means (SRM) and meaningful differences (MDs).
EQ-VAS and EQ-index scores correlated well with disease activity indices and differed significantly between active disease and remission groups. All scores were reliable in test-retest (ICC: EQ-VAS: 0.89; UK-index: 0.76; German EQ-index: 0.72). According to SRM, EQ-VAS was more responsive for deterioration in health than for improvement in health and was more responsive than index scores. Index scores were most responsive for deterioration in health in subjects in remission and for improved health in subjects with active disease. MDs for improved health (EQ-VAS: 10.9; UK EQ-index: 0.076; German EQ-index: 0.050) and deteriorated health (EQ-VAS: -14.4; UK EQ-index: -0.109; German EQ-index: -0.067) were significant, but MD of EQ-VAS also differed significantly according to disease activity.
The EQ-5D generates valid, reliable, and responsive preference-based evaluations of health in CD and UC. EQ-VAS scores were more responsive than EQ-5D index scores. Thus, small health differences that are important from the patient's perspective may not be reflected in the EQ-index.
EuroQol（EQ）-5D 问卷是一种衡量与健康相关的生活质量的通用工具。在大量克罗恩病（CD）和溃疡性结肠炎（UC）患者中评估了其有效性、可靠性和反应能力。
EQ-5D 最初完成（270 例 CD 和 232 例 UC 患者），4 周后（447 例患者）使用过渡问题对健康变化进行评分。通过标准化反应均值（SRM）和有意义差异（MD）评估 EQ 视觉模拟量表（EQ-VAS）和英国（UK）指数和德国 EQ-5D 指数（EQ 指数）评分对报告的健康变化的反应能力。
EQ-VAS 和 EQ 指数评分与疾病活动指数密切相关，在活动疾病和缓解组之间差异显著。所有评分在测试 - 重测（ICC：EQ-VAS：0.89；英国指数：0.76；德国 EQ 指数：0.72）中均可靠。根据 SRM，EQ-VAS 对健康恶化的反应比健康改善更为敏感，并且比指数评分更为敏感。在缓解期患者中，指数评分对健康恶化的反应最敏感，而在活动期患者中，对健康改善的反应最敏感。健康改善的 MD（EQ-VAS：10.9；英国 EQ 指数：0.076；德国 EQ 指数：0.050）和健康恶化的 MD（EQ-VAS：-14.4；英国 EQ 指数：-0.109；德国 EQ 指数：-0.067）均有统计学意义，但 EQ-VAS 的 MD 也根据疾病活动程度而有显著差异。
EQ-5D 可对 CD 和 UC 患者的健康产生有效、可靠和敏感的偏好评估。EQ-VAS 评分比 EQ-5D 指数评分更敏感。因此，从患者角度来看重要的较小健康差异可能不会反映在 EQ 指数中。
