König Hans-Helmut, Ulshöfer Anita, Gregor Michael, von Tirpitz Christian, Reinshagen Max, Adler Guido, Leidl Reiner
Department of Health Economics, University of Ulm, Germany.
Eur J Gastroenterol Hepatol. 2002 Nov;14(11):1205-15. doi: 10.1097/00042737-200211000-00008.
The EuroQol EQ-5D is a generic questionnaire for describing and valuing patients' health-related quality of life. The purpose of the study was to analyse the construct validity, criterion validity, test-retest reliability and responsiveness of the EQ-5D in patients with inflammatory bowel disease.
152 consecutive patients with inflammatory bowel disease (123 with Crohn's disease and 29 with ulcerative colitis) completed the EQ-5D, the SF-36 and the Inflammatory Bowel Disease Questionnaire (IBDQ). Of the study group, 66 patients filled in the EQ-5D a second time after a 2-week gap, including a transition question. Disease activity was measured by the Crohn's Disease Activity Index (CDAI) and by Rachmilewitz's Clinical Activity Index (CAI).
The EQ-5D showed a moderate ceiling effect. Correlation between the EQ-5D visual analogue scale (EQ VAS) score and CDAI/CAI was r = -0.65/r = -0.71 (both P < 0.001). Levels of responses to EQ-5D items and the EQ VAS score were significantly better for patients in remission than for patients with active disease (all P < 0.01). For the total sample, coefficients of correlation between the EQ VAS score and SF-36 and IBDQ scores ranged between 0.37 and 0.73 (all P < 0.0001). When repeated, the EQ-5D was reliable in stable patients (intraclass correlation coefficient for EQ VAS = 0.77, kappa statistic for items 0.39 to 1.00); the EQ VAS was responsive in patients who, in the transition question, indicated an improvement in health state (effect size 0.79).
The EQ-5D is reasonably valid, reliable and responsive in patients with inflammatory bowel disease. It can be used to generate preference-based valuations of health-related quality of life in inflammatory bowel disease.
欧洲五维健康量表（EuroQol EQ - 5D）是一种用于描述和评估患者健康相关生活质量的通用问卷。本研究旨在分析EQ - 5D在炎症性肠病患者中的结构效度、效标效度、重测信度和反应度。
152例连续性炎症性肠病患者（123例克罗恩病患者和29例溃疡性结肠炎患者）完成了EQ - 5D、健康调查简表（SF - 36）和炎症性肠病问卷（IBDQ）。在研究组中，66例患者在间隔2周后再次填写EQ - 5D，包括一个过渡问题。疾病活动度通过克罗恩病活动指数（CDAI）和拉赫米列维茨临床活动指数（CAI）进行测量。
EQ - 5D显示出中度天花板效应。EQ - 5D视觉模拟量表（EQ VAS）评分与CDAI/CAI之间的相关性为r = -0.65/r = -0.71（均P < 0.001）。缓解期患者对EQ - 5D项目的反应水平和EQ VAS评分显著优于活动期疾病患者（均P < 0.01）。对于总样本，EQ VAS评分与SF - 36和IBDQ评分之间的相关系数在0.37至0.73之间（均P < 0.0001）。重复测量时，EQ - 5D在病情稳定的患者中具有可靠性（EQ VAS的组内相关系数 = 0.77，项目的kappa统计量为0.39至1.00）；在过渡问题中表明健康状况有所改善的患者中，EQ VAS具有反应度（效应量为0.79）。
EQ - 5D在炎症性肠病患者中具有合理的效度、信度和反应度。它可用于生成基于偏好的炎症性肠病健康相关生活质量评估。
