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美洲皮肤利什曼病患者白细胞介素17的产生情况。

Interleukin 17 production among patients with American cutaneous leishmaniasis.

作者信息

Bacellar Olívia, Faria Daniela, Nascimento Márcia, Cardoso Thiago M, Gollob Kenneth J, Dutra Walderez O, Scott Phillip, Carvalho Edgar M

机构信息

Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador-Bahia, Brazil.

出版信息

J Infect Dis. 2009 Jul 1;200(1):75-8. doi: 10.1086/599380.

DOI:10.1086/599380
PMID:19476435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2732405/
Abstract

Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.

摘要

白细胞介素17（IL-17）在炎症和自身免疫中起关键作用。关于原生动物感染中的IL-17，人们了解甚少。在此，我们发现，与未感染的对照受试者的淋巴细胞相比，黏膜利什曼病和皮肤利什曼病患者的淋巴细胞产生的IL-17水平更高（P<0.01）。与皮肤利什曼病患者的组织相比，黏膜利什曼病患者的组织中表达IL-17的细胞数量有增加的趋势，且表达IL-17的细胞数量与病变部位的细胞炎症存在直接相关性（r2 = 0.86；P<0.001）。这些数据支持IL-17在利什曼病炎症反应发病机制中的作用。

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Interleukin 17 production among patients with American cutaneous leishmaniasis.

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本文引用的文献

[1]
Recent developments leading toward a paradigm switch in the diagnostic and therapeutic approach to human leishmaniasis.

Curr Opin Infect Dis. 2008-10

[2]
Pentoxifylline down modulate in vitro T cell responses and attenuate pathology in Leishmania and HTLV-I infections.

Int Immunopharmacol. 2008-10

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Local immunological factors associated with recurrence of mucosal leishmaniasis.

Clin Immunol. 2008-9

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Induction and effector functions of T(H)17 cells.

Nature. 2008-6-19

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Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses.

J Immunol. 2008-6-1

[6]
Interleukin-17 as an effector molecule of innate and acquired immunity against infections.

Microbiol Immunol. 2007

[7]
Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis.

Infect Immun. 2005-12

[8]
Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis.

Immunol Lett. 2005-11-15

[9]
Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects.

Int Arch Allergy Immunol. 2005

[10]
Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection.

Infect Immun. 2005-1

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