Branicky Robyn, Schafer Wiliam R
Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Neuron. 2009 May 28;62(4):458-60. doi: 10.1016/j.neuron.2009.05.005.
Biogenic amines are typically regarded as neuromodulators rather than fast-acting neurotransmitters. In this issue of Neuron, Pirri et al. report the characterization of LGC-55 in C. elegans, the first identified tyramine-gated chloride channel. This study suggests that the roles of classical and trace biogenic amines in all organisms may need to be reconsidered.
生物胺通常被视为神经调质而非快速作用的神经递质。在本期《神经元》杂志中，皮里等人报告了对秀丽隐杆线虫中LGC - 55的特性描述，这是首个被鉴定出的酪胺门控氯离子通道。这项研究表明，经典和微量生物胺在所有生物体中的作用可能需要重新审视。
