Bergmann W, Burgener I A, Roccabianca P, Rytz U, Welle M
Institute of Animal Pathology, Vetsuisse Faculty, University of Berne, Switzerland.
J Comp Pathol. 2009 Aug-Oct;141(2-3):195-8. doi: 10.1016/j.jcpa.2009.03.009. Epub 2009 May 27.
An 8-year-old crossbred dog was presented with a one-month history of progressive weakness, respiratory impairment and abdominal distension. Surgical exploration revealed the presence of a splenic mass that infiltrated the mesentery and was adherent to the stomach and pancreas. The mass was composed of highly cellular areas of spindle-shaped cells arranged in interlacing bundles, streams, whorls and storiform patterns (Antoni A pattern) and less cellular areas with more loosely arranged spindle to oval cells (Antoni B pattern). The majority of neoplastic cells expressed vimentin, S-100 and glial fibrillary acidic protein (GFAP), but did not express desmin, alpha-smooth muscle actin or factor VIII. These morphological and immunohistochemical findings characterized the lesion as a malignant peripheral nerve sheath tumour (PNST). Primary splenic PNST has not been documented previously in the dog.
一只8岁的杂种犬出现进行性虚弱、呼吸功能障碍和腹胀1个月的病史。手术探查发现脾脏有一肿物,该肿物浸润肠系膜并与胃和胰腺粘连。肿物由梭形细胞构成的高细胞区组成,这些细胞呈交错束状、条索状、漩涡状和席纹状排列(Antoni A型),以及细胞较少、梭形至椭圆形细胞排列较疏松的区域(Antoni B型)。大多数肿瘤细胞表达波形蛋白、S-100和胶质纤维酸性蛋白(GFAP),但不表达结蛋白、α-平滑肌肌动蛋白或因子VIII。这些形态学和免疫组化结果表明该病变为恶性外周神经鞘瘤(PNST)。原发性脾脏PNST此前在犬中未见报道。