Rinaldi Valentina, Nordio Laura, Vignoli Massimo, Masci Stefano, Ressel Lorenzo, Crisi Paolo Emidio
Department of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100 Teramo, Italy.
San Marco Veterinary Clinic and Laboratory, Division of Pathology, 35030 Veggiano, Italy.
Vet Sci. 2025 May 26;12(6):521. doi: 10.3390/vetsci12060521.
Hepatic sarcomas are rare and aggressive tumors in veterinary medicine, with limited reports in the literature. This case report describes a canine hepatic myofibroblastic sarcoma in a 5-year-old spayed female Dobermann. The dog presented with abdominal enlargement and was diagnosed with a large hepatic mass following comprehensive diagnostic evaluations, including blood tests, imaging, and histopathology. Histological and immunohistochemical analyses confirmed the tumor's myofibroblastic origin, characterized by positivity for markers such as vimentin, glial fibrillary acidic protein (GFAP), nerve growth factor receptor (NGFR), alpha-smooth muscle actin (SMA), and muscular actin (HHF35). Treatment involved a combination of intense-dose chemotherapy using doxorubicin and a subsequent metronomic chemotherapy protocol, which resulted in prolonged survival of over 690 days at the time this manuscript was written. This case highlights the importance of extensive diagnostic and immunohistochemical profiling in the accurate classification of and treatment planning for hepatic sarcomas, and emphasizes the role of advanced veterinary diagnostics in improving patient outcomes. Future studies with larger sample sizes are needed to enhance understanding of the biological behavior and optimal therapeutic strategies for such rare tumors.
肝肉瘤在兽医学中是罕见且侵袭性强的肿瘤，文献报道有限。本病例报告描述了一只5岁绝育雌性杜宾犬患肝肌成纤维细胞肉瘤的情况。该犬出现腹部肿大，在进行包括血液检查、影像学检查和组织病理学检查在内的全面诊断评估后，被诊断为肝脏有一个大肿块。组织学和免疫组织化学分析证实了肿瘤的肌成纤维细胞起源，其特征是波形蛋白、胶质纤维酸性蛋白（GFAP）、神经生长因子受体（NGFR）、α平滑肌肌动蛋白（SMA）和肌动蛋白（HHF35）等标志物呈阳性。治疗采用了阿霉素高强度化疗与后续的节拍化疗方案相结合的方法，在撰写本手稿时，该犬存活时间延长至690多天。本病例突出了广泛的诊断和免疫组织化学分析在肝肉瘤准确分类和治疗规划中的重要性，并强调了先进的兽医诊断在改善患者预后方面的作用。需要进行更大样本量的未来研究，以增进对此类罕见肿瘤生物学行为和最佳治疗策略的理解。
