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在乍得恩贾梅纳接受一线高效抗逆转录病毒治疗的艾滋病毒感染成人中，抗逆转录病毒药物耐药性的高发生率。

High frequency of antiretroviral drug resistance among HIV-infected adults receiving first-line highly active antiretroviral therapy in N'Djamena, Chad.

作者信息

Koyalta Donato, Charpentier Charlotte, Beassamda Jatibi, Rey Elisabeth, Si-Mohamed Ali, Djemadji-Oudjeil Noël, Bélec Laurent

机构信息

Hôpital Général de Référence Nationale, N'Djamena, Chad.

出版信息

Clin Infect Dis. 2009 Jul 1;49(1):155-9. doi: 10.1086/599611.

DOI:10.1086/599611
PMID:19480574
Abstract

Antiretroviral drug resistance was evaluated in 88 adults infected with human immunodeficiency virus, most with subtype CRF11_cpx, who had received a first-line antiretroviral regimen for 6 months, in N'Djamena, Chad. A total of 47 patients (53%) had detectable viral load at month 6, and 56 (64%) had at least 1 antiretroviral resistance mutation observed.

摘要

在乍得恩贾梅纳，对88名感染人类免疫缺陷病毒的成年人进行了抗逆转录病毒药物耐药性评估，这些成年人大多感染的是CRF11_cpx亚型，他们接受一线抗逆转录病毒治疗方案已达6个月。共有47名患者（53%）在第6个月时病毒载量可检测到，56名患者（64%）观察到至少有1种抗逆转录病毒耐药性突变。

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