Solovyov A, Palacios G, Briese T, Lipkin W I, Rabadan R
Physics Department, Princeton University, Princeton, United States.
Euro Surveill. 2009 May 28;14(21):19224. doi: 10.2807/ese.14.21.19224-en.
In March and April 2009, a new strain of influenza A(H1N1) virus has been isolated in Mexico and the United States. Since the initial reports more than 10,000 cases have been reported to the World Health Organization, all around the world. Several hundred isolates have already been sequenced and deposited in public databases. We have studied the genetics of the new strain and identified its closest relatives through a cluster analysis approach. We show that the new virus combines genetic information related to different swine influenza viruses. Segments PB2, PB1, PA, HA, NP and NS are related to swine H1N2 and H3N2 influenza viruses isolated in North America. Segments NA and M are related to swine influenza viruses isolated in Eurasia.
2009年3月和4月,一种新型甲型H1N1流感病毒在墨西哥和美国被分离出来。自最初报告以来,全球已向世界卫生组织报告了10000多例病例。数百个分离株已被测序并存入公共数据库。我们研究了这种新型病毒的遗传学,并通过聚类分析方法确定了其最密切的亲缘关系。我们发现,这种新型病毒结合了与不同猪流感病毒相关的遗传信息。PB2、PB1、PA、HA、NP和NS片段与在北美分离出的猪H1N2和H3N2流感病毒有关。NA和M片段与在欧亚大陆分离出的猪流感病毒有关。