Oloyede O B, Sunmonu T O
Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
Food Chem Toxicol. 2009 Aug;47(8):2067-70. doi: 10.1016/j.fct.2009.05.026. Epub 2009 May 27.
Bread samples from five different locations (Gaa-Akanbi, Saw-Mill, Oloje, Fate-Basin and Zango) in Ilorin metropolis, Central Nigeria were analyzed for their potassium bromate content before they were employed as a source of carbohydrate in the formulation of diet for albino rats. A total of sixty (60) albino rats (Rattus norvegicus) were grouped into six (6) of ten (10) rats each. The rats in the first group served as control and they were placed on diet formulated with bromate-free bread. Animals in Groups 2-6 were placed on diet formulated with bread samples obtained from the five different locations in Ilorin metropolis. At the expiration of thirty (30) days feeding period, the animals were sacrificed and blood samples, liver and kidney tissues were collected for the assay of ALP, AST and ALT activities. The results showed a significant reduction (p<0.05) in the activities of these enzymes in the tissues when compared with the control. However, a significant increase (p<0.05) was observed in the activities of the selected serum enzymes. Overall, the data indicate adverse effects on the liver and kidney of rats fed on diet containing potassium bromate.
对尼日利亚中部伊洛林市五个不同地点（加阿 - 阿坎比、锯木厂、奥洛杰、命运盆地和赞戈）的面包样本进行了溴酸钾含量分析，然后将其用作白化大鼠饮食配方中的碳水化合物来源。总共六十（60）只白化大鼠（褐家鼠）被分成六（6）组，每组十（10）只。第一组大鼠作为对照组，喂食不含溴酸盐的面包所配制的饮食。第2 - 6组的动物喂食用从伊洛林市五个不同地点获取的面包样本所配制的饮食。在三十（30）天的喂食期结束时，处死动物并采集血液样本、肝脏和肾脏组织，用于检测碱性磷酸酶（ALP）、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的活性。结果显示，与对照组相比，这些组织中这些酶的活性显著降低（p<0.05）。然而，所选血清酶的活性显著增加（p<0.05）。总体而言，数据表明喂食含溴酸钾饮食的大鼠的肝脏和肾脏受到了不良影响。
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