Department of Biochemistry, University of Ilorin, PMB 1515 Ilorin, Nigeria.
Food Chem Toxicol. 2010 Mar;48(3):898-902. doi: 10.1016/j.fct.2009.12.030. Epub 2010 Jan 6.
The effects of Tetracarpidium conophorum nut oil-based diet on the growth performance and some biochemical constituents of rat tissues was investigated following a feeding period of 6 weeks. The results revealed that the volume of water taken, the amount of feed consumed and the weight gained by the animals maintained on the nut oil-based diet were not significantly (P>0.05) different from those fed on soybean oil-based diet. The reduction in the activities of ALP, GOT and GPT in the liver and heart of animals fed on the nut oil-based diet was accompanied by increase in the serum enzymes. The nut oil-based diet significantly reduced (P<0.05) serum concentrations of total cholesterol and HDL-C whereas triglycerides and atherogenic index increased. The serum LDL-C level of the nut oil-based diet fed animals compared well with those of soybean oil-based diet. These alterations suggested that adverse effects have occurred, possibly by altered membrane permeability of the hepatocytes and cardiac cells. Similar alterations in the serum lipids of animals maintained on nut oil-based diet also portends cardiovascular risk. Although, T. conophorum nut oil did not adversely affect growth performance and the feeding appetite of the animals, it is not completely 'safe' for consumption.
研究了 6 周喂养期后，麻疯树坚果油饮食对大鼠组织生长性能和一些生化成分的影响。结果表明，食用麻疯树坚果油饮食的动物的饮水量、采食量和体重增加与食用大豆油饮食的动物没有显著差异（P>0.05）。食用麻疯树坚果油饮食的动物的肝脏和心脏中 ALP、GOT 和 GPT 的活性降低，同时血清酶升高。麻疯树坚果油饮食显著降低了（P<0.05）血清总胆固醇和高密度脂蛋白胆固醇的浓度，而甘油三酯和致动脉粥样硬化指数增加。与大豆油饮食组相比，食用麻疯树坚果油饮食的动物的血清 LDL-C 水平相当。这些变化表明，可能是由于肝细胞和心肌细胞的膜通透性改变，发生了不良反应。食用麻疯树坚果油的动物的血清脂质也发生了类似的变化，预示着心血管风险。尽管麻疯树坚果油并没有对动物的生长性能和食欲产生不良影响，但它并不是完全“安全”的。
