根据体重指数、体重、年龄及其他因素的口服避孕药有效性

Oral contraceptive effectiveness according to body mass index, weight, age, and other factors.

作者信息

Dinger Jürgen C, Cronin Maureen, Möhner Sabine, Schellschmidt Ilka, Minh Thai Do, Westhoff Carolyn

机构信息

ZEG-Center for Epidemiology and Health Research, Berlin, Germany.

出版信息

Am J Obstet Gynecol. 2009 Sep;201(3):263.e1-9. doi: 10.1016/j.ajog.2009.03.017. Epub 2009 May 30.

DOI:10.1016/j.ajog.2009.03.017

PMID:19481720

Abstract

OBJECTIVE

The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other factors.

STUDY DESIGN

In a planned secondary analysis, we used data from the European Active Surveillance Study on Oral Contraceptives, which was a prospective active cohort surveillance study of 59,510 OC users, to assess the effectiveness of OCs overall and by BMI, weight, age, duration of use, ethinylestradiol dose, regimen type, starting/switching status, and parity. Self-reported unplanned pregnancies during OC use were confirmed by interview.

RESULTS

An analysis of OC effectiveness (112,659 women-years of exposure and 545 unplanned pregnancies) found little variation in effectiveness by BMI/weight. Failure rates decreased after 30 years of age and with an increasing duration of use.

CONCLUSION

OC users in Europe reported high contraceptive effectiveness with "typical use." Failure rates decreased with age and duration of use. BMI and weight had little, if any, influence on effectiveness.

摘要

目的

本研究旨在根据体重指数（BMI）、体重、年龄及其他因素评估欧洲口服避孕药（OC）的使用效果。

研究设计

在一项计划中的二次分析中，我们使用了来自欧洲口服避孕药主动监测研究的数据，该研究是一项对59,510名口服避孕药使用者进行的前瞻性主动队列监测研究，以评估口服避孕药总体以及按BMI、体重、年龄、使用时长、炔雌醇剂量、用药方案类型、开始/转换状态和生育次数划分的使用效果。通过访谈确认口服避孕药使用期间自我报告的意外怀孕情况。