Ganesvaran G, Greer J M, Pender M P
Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Mult Scler. 2009 Jun;15(6):763-6. doi: 10.1177/1352458509103612.
We identified a subgroup of 20 patients with multiple sclerosis (MS) and psoriasis within a total group of 692 patients with MS.
There was a high (80%) incidence of brainstem and/or cerebellar involvement and a high mean (+/-SD) Multiple Sclerosis Severity Score (6.06 +/- 2.88) in this subgroup. Of the patients who were human leukocyte antigen typed, 53% carried the MS-associated allele, DRB11501, and 27% carried the psoriasis-associated DRB107 allele.
The high incidence of brainstem and cerebellar involvement might be explained by the greater severity of MS and the high frequency (60%) of carriage of DRB104, DRB107, and/or DRB1*13 alleles, which are associated with brainstem and cerebellar involvement in MS.
在692例多发性硬化症（MS）患者的总群体中，我们识别出了一个由20例患有MS和银屑病的患者组成的亚组。
该亚组中脑干和/或小脑受累的发生率很高（80%），且平均多发性硬化症严重程度评分较高（±标准差，6.06±2.88）。在进行了人类白细胞抗原分型的患者中，53%携带与MS相关的等位基因DRB11501，27%携带与银屑病相关的DRB107等位基因。
脑干和小脑受累的高发生率可能是由于MS病情更严重以及DRB104、DRB107和/或DRB1*13等位基因的携带频率较高（60%）所致，这些等位基因与MS中的脑干和小脑受累有关。
