Department of Neurology, Hospital General de Tomelloso, Tomelloso, Ciudad Real, Spain.
J Neurol. 2012 Dec;259(12):2758-60. doi: 10.1007/s00415-012-6713-1. Epub 2012 Oct 25.
Beta-interferon therapy is known to trigger psoriasis, but this effect has not been previously reported for other multiple sclerosis treatments, such as natalizumab. The following is a case report. A 31-year-old woman affected by psoriasis and relapsing-remitting multiple sclerosis suffered a severe worsening of psoriasis symptoms during natalizumab treatment and acquired a drug-resistant course. This case suggests that aggravation of psoriasis might be a rare side effect of natalizumab, and that clinicians should be aware of the possibility of paradoxical activation of autoimmune diseases during its treatment.
β干扰素疗法已知可引发银屑病，但这一效应以前并未在其他多发性硬化症治疗药物（如那他珠单抗）中报告过。以下是一则病例报告。一名 31 岁女性患有银屑病和复发缓解型多发性硬化症，在接受那他珠单抗治疗期间银屑病症状严重恶化，并发展为耐药病程。该病例提示银屑病加重可能是那他珠单抗的一种罕见副作用，临床医生在治疗过程中应注意自身免疫性疾病发生矛盾性激活的可能性。
