Doherty P C, Zinkernagel R M
Immunology. 1976 Jul;31(1):27-32.
Mice exposed to paramyxovirus (Sendai) generate specifically sensitized thymus-derived lymphocytes (T cells) which, in an in vitro 51Cr release assay, interact only with virus-infected target cells sharing strong transplantation antigens. Reciprocal exclusion of cytotoxic T-cell activity is found for Sendai virus, lymphocytic choriomeningitis virus and ectromelia virus. Immune T cells are detected as early as 3 days after intraperitoneal inoculation with a large dose of Sendai virus, and cytotoxicity is generally maximal on days 5-7. Lysis is restricted to interactions where sensitized lymphocytes and virus-infected target cells (fibroblasts, tumour cells or macrophages) are compatible at the K or the D locus of one H-2 haplotype. Identity of immune response (Ir) genes is neither sufficient nor necessary. Levels of T-cell responsiveness show some variation with H-2 type. Cytotoxic T-cell activity associated with H-2b is less than that recognized for H-2k or H-2d. These differences are, however, not obviously related to Ir gene control.
暴露于副粘病毒（仙台病毒）的小鼠会产生特异性致敏的胸腺衍生淋巴细胞（T细胞），在体外51Cr释放试验中，这些T细胞仅与共享强移植抗原的病毒感染靶细胞相互作用。对于仙台病毒、淋巴细胞性脉络丛脑膜炎病毒和埃可病毒，发现了细胞毒性T细胞活性的相互排斥。在腹腔内接种大剂量仙台病毒后3天即可检测到免疫T细胞，细胞毒性通常在第5 - 7天达到最大。细胞裂解仅限于致敏淋巴细胞与病毒感染靶细胞（成纤维细胞、肿瘤细胞或巨噬细胞）在一个H - 2单倍型的K或D位点相容的相互作用。免疫反应（Ir）基因的一致性既不充分也不必要。T细胞反应性水平随H - 2类型有一些变化。与H - 2b相关的细胞毒性T细胞活性低于H - 2k或H - 2d所识别的活性。然而，这些差异与Ir基因控制并无明显关联。
