鼠细胞毒性 T 细胞对甲病毒的反应主要与 H-2D(k) 相关。
Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).
机构信息
Department of Microbiology, John Curtin School of Medical Research, Australien National University, 2601, Canberra, A.C.T., Australia.
出版信息
Immunogenetics. 1978 Dec;7(1):551-61. doi: 10.1007/BF01844044.
A secondary in vitro response to alphaviruses Bebaru, Sindbis, and Semliki Forest is described. Optimum response appears at day 5-6 of culture. The cells responsible for lytic activity are nonadherent, Φ-positive, Ig(-), and mainly Ly-2.1 positive. Out of five haplotypes tested (H- 2 ( d ),H- 2 ( b ),H- 2 ( s ),H- 2 ( q ), andH- 2 ( k )) onlyH- 2 ( k ) was a responder. Genetic mapping of the response located it solely in theD region of theH- 2 complex. The other four haplotypes responded with a high antiself activity after a second stimulation with viruses. This antiself response also maps in theD region of theH- 2 complex. No complementation was observed in F(1) hybrids between responder and nonresponder strains.
描述了对阿尔巴病毒 Bebaru、辛德比斯和塞米利基森林的二次体外反应。最佳反应出现在培养的第 5-6 天。负责裂解活性的细胞是非贴壁的、Φ阳性、Ig(-)，主要为 Ly-2.1 阳性。在测试的五个单倍型（H-2(d)、H-2(b)、H-2(s)、H-2(q)和 H-2(k)）中，只有 H-2(k)是反应者。对反应的遗传作图将其仅定位在 H-2 复合物的 D 区域。其他四个单倍型在第二次用病毒刺激后，表现出高的抗自身活性。这种抗自身反应也映射在 H-2 复合物的 D 区域。在反应者和非反应者品系之间的 F(1)杂种中未观察到互补。
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