利妥昔单抗治疗自身免疫性肺泡蛋白沉积症。
Rituximab therapy in autoimmune pulmonary alveolar proteinosis.
作者信息
Borie R, Debray M-P, Laine C, Aubier M, Crestani B
机构信息
Service de Pneumologie A, Faculté de médecine Denis Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Université Paris 7, Paris, France.
出版信息
Eur Respir J. 2009 Jun;33(6):1503-6. doi: 10.1183/09031936.00160908.
PMID:19483052
Abstract
Idiopathic pulmonary alveolar proteinosis is presumed to be an autoimmune disorder that may lead to pulmonary insufficiency. However, steroids do not appear to be effective and the standard of therapy is whole-lung lavage. We report the first case of successful therapy with rituximab, which addresses the pathogenic mechanism of pulmonary alveolar proteinosis.
摘要
特发性肺泡蛋白沉积症被认为是一种可能导致肺功能不全的自身免疫性疾病。然而，类固醇似乎并无效果，而标准治疗方法是全肺灌洗。我们报告了首例使用利妥昔单抗成功治疗的病例，该药物针对肺泡蛋白沉积症的致病机制发挥作用。
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