Dhattiwala A S
Indian J Physiol Pharmacol. 1977 Jan-Mar;21(1):25-30.
Imipramine (2-10 microng/ml) noncompetitively inhibited acetylcholine responses of the frog rectus abdominis muscle, and markedly inhibited the contracture produced by carbachol and succinylcholine without affecting the contracture produced by KCl, caffeine, and chlorpromazine. The twitch responses to indirect and direct stimulation of the rat phrenic nerve-diaphragm and the frog sciatic nerve-gastrocnemius were first augmented and then depressed markedly and irreversibly by imipramine (5-20 microng/ml). The indirect stimulation was inhibited earlier and to a greater degree than the direct stimulation. The blockade in the nerve-sartorius developed and progressed quickly without prior augmented responses, and with a parallel time course for indirect and direct stimulation. On the frog rectus, physostigmine antagonised whereas d-tubocurarine and CaCl2 increased the imipramine-induced inhibition. In the nerve muscle preparations, physostigmine, CaCl2 and KCl did not affect the neuromuscular blockade produced by imipramine; tubocurarine (0.05 microng/ml) markedly increased the blocking effect of imipramine (20 microng/ml) on the rat phrenic nerve-diaphragm. The results have been discussed in relation to the memberane stabilizing and the calcium releasing actions of imipramine.
丙咪嗪（2 - 10微克/毫升）非竞争性抑制青蛙腹直肌的乙酰胆碱反应，并显著抑制卡巴胆碱和琥珀酰胆碱引起的挛缩，而不影响氯化钾、咖啡因和氯丙嗪引起的挛缩。丙咪嗪（5 - 20微克/毫升）对大鼠膈神经 - 膈肌以及青蛙坐骨神经 - 腓肠肌间接和直接刺激的抽搐反应，先是增强，然后显著且不可逆地减弱。间接刺激比直接刺激更早且更明显地受到抑制。神经 - 缝匠肌的阻滞迅速发展且进展迅速，没有先前的增强反应，间接和直接刺激的时间进程平行。在青蛙腹直肌上，毒扁豆碱起拮抗作用，而d - 筒箭毒碱和氯化钙增强丙咪嗪诱导的抑制作用。在神经肌肉标本中，毒扁豆碱、氯化钙和氯化钾不影响丙咪嗪产生的神经肌肉阻滞；筒箭毒碱（0.05微克/毫升）显著增强丙咪嗪（20微克/毫升）对大鼠膈神经 - 膈肌的阻滞作用。已结合丙咪嗪的膜稳定作用和钙释放作用对结果进行了讨论。
