Abdel-Aziz A, Osman O H
Acta Physiol Acad Sci Hung. 1975;46(2):173-9.
Using the rat phrenic nerve diaphragm, cyproheptadine at concentrations of 1 to 8 mug/ml did not affect or slightly augmented indirect muscle twitches, but potentiated blockade by tubocurarine, decamethonium and succinylcholine, and antagonized the augmentation of twitches by neostigmine. Ketamine, choline and tetraethylammonium at concentrations causing no blockade produced, when given after cyproheptadine (6 mug/ml), a high degree of blockade. At concentrations of 9 to 20 mug/ml, cyproheptadine induced neuromuscular blockade which was slow in onset, more apparent at higher rate of stimulation and was not reversed by neostigmine, choline or tetraethylammonium. In the cat tibialis anterior muscle, it potentiated blockade by tubocurarine, decamethonium and succinylcholine, and blocked acetylcholine twitches. In the chick biventer cervicis muscle, the durg was more effective in blocking indirect twitches than responses to carbachol.
使用大鼠膈神经膈肌标本，浓度为1至8微克/毫升的赛庚啶对间接肌肉抽搐无影响或略有增强，但增强了筒箭毒碱、十烃季铵和琥珀酰胆碱的阻滞作用，并拮抗新斯的明引起的抽搐增强。在赛庚啶（6微克/毫升）给药后给予浓度不产生阻滞作用的氯胺酮、胆碱和四乙铵，会产生高度阻滞。浓度为9至20微克/毫升时，赛庚啶诱导的神经肌肉阻滞起效缓慢，在较高刺激频率下更明显，且新斯的明、胆碱或四乙铵不能使其逆转。在猫胫前肌中，它增强了筒箭毒碱、十烃季铵和琥珀酰胆碱的阻滞作用，并阻断乙酰胆碱引起的抽搐。在鸡颈二腹肌中，该药物阻断间接抽搐比阻断对卡巴胆碱的反应更有效。
