Delamarter R B, Sherman J E, Carr J B
Division of Orthopaedic Surgery, University of California, School of Medicine, Los Angeles.
Spine (Phila Pa 1976). 1991 Sep;16(9):1022-9.
An animal model of cauda equina syndrome was developed. Neurologic recovery was analyzed following immediate, early, and delayed decompression. Five experimental groups, each containing six dogs, were studied. Compression of the cauda equina was performed in all 30 dogs following an L6-7 laminectomy. The cauda equina was constricted by 75% in each group. The first group was constricted and immediately decompressed. The remaining groups were constricted for 1 hour, 6 hours, 24 hours, and 1 week, respectively, before being decompressed. Somatosensory evoked potentials were performed before and after surgery, before and immediately after decompression, and 6 weeks following decompression. Daily neurologic exams using the Tarlov grading scale were performed. At 6 weeks postdecompression, all dogs were killed, and the neural elements analyzed histologically. Following compression, all 30 dogs had significant lower extremity weakness, tail paralysis, and urinary incontinence. All dogs recovered significant motor function 6 weeks following decompression. The dogs with immediate decompression generally recovered neurologic function within 2-5 days. The dogs receiving 1-hour and 6-hour compression recovered within 5-7 days. The dogs receiving 24-hour compression remained paraparetic 5-7 days, with bladder dysfunction for 7-10 days and tail dysfunction persisting for 4 weeks. The dogs with compression for 1 week were paraparetic (Tarlov Grade 2 or 3) and incontinent during the duration of cauda equina compression. They recovered to walking by 1 week and Tarlov Grade 5 with bladder and tail control at the time of euthanasia. Immediately after compression, all five groups demonstrated at least 50% deterioration of the posterior tibial nerve evoked potential amplitudes.(ABSTRACT TRUNCATED AT 250 WORDS)
建立了马尾综合征的动物模型。分析了即刻、早期和延迟减压后的神经恢复情况。研究了五个实验组，每组包含六只狗。在所有30只狗进行L6 - 7椎板切除术后对马尾进行压迫。每组马尾均被压缩75%。第一组受压后立即减压。其余组分别在受压1小时、6小时、24小时和1周后减压。在手术前、减压前和减压后即刻以及减压后6周进行体感诱发电位检查。使用塔尔洛夫分级量表进行每日神经学检查。在减压后6周，所有狗均被处死，并对神经组织进行组织学分析。受压后，所有30只狗均出现明显的下肢无力、尾部麻痹和尿失禁。减压6周后所有狗均恢复了显著的运动功能。即刻减压的狗一般在2 - 5天内恢复神经功能。受压1小时和6小时的狗在5 - 7天内恢复。受压24小时的狗在5 - 7天内仍有双下肢轻瘫，膀胱功能障碍持续7 - 10天，尾部功能障碍持续4周。受压1周的狗在马尾受压期间为双下肢轻瘫（塔尔洛夫分级2或3级）且大小便失禁。它们在1周时恢复行走，在安乐死时达到塔尔洛夫5级，膀胱和尾部功能可控。受压后即刻，所有五组胫后神经诱发电位振幅至少下降50%。（摘要截断于250字）
