Department of Psychiatry, University of Iowa, Iowa City, IA 52242-1000, USA.
J Clin Exp Neuropsychol. 2010 Mar;32(3):231-8. doi: 10.1080/13803390902926184. Epub 2009 May 29.
Huntington's disease (HD) is associated with a variety of cognitive deficits, as well as motor and psychiatric disturbances. As clinical trials for HD evolve, briefer screening instruments will be needed to determine cognitive effects of interventions. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) may fill this gap. A total of 75 participants diagnosed with HD were evaluated with the RBANS, as well as several other scales typically used in HD. RBANS performances for these participants fell significantly below expectations for the Total Scale score, all five Indexes, and 11 of the 12 individual subtests. Cognitive scores on the RBANS were also significantly related to other markers of HD, including motor abnormalities, functional abilities, and other cognitive scores. Although additional research is needed, the current study supports the clinical applicability of the RBANS in patients with HD.
亨廷顿病（HD）与多种认知缺陷、运动和精神障碍有关。随着 HD 临床试验的发展，需要更简短的筛选工具来确定干预措施对认知的影响。重复性成套神经心理状态测验（RBANS）可能会填补这一空白。共有 75 名被诊断为 HD 的参与者接受了 RBANS 以及其他几种通常用于 HD 的量表的评估。这些参与者的 RBANS 表现明显低于总评分、五个指数和 12 个单项测试中的 11 个的预期。RBANS 的认知评分也与 HD 的其他标志物显著相关，包括运动异常、功能能力和其他认知评分。虽然还需要进一步的研究，但目前的研究支持 RBANS 在 HD 患者中的临床适用性。
