Department of Neurosciences, University of California, San Diego, San Diego, California.
Department of Psychology, San Diego State University, San Diego, California.
Cogn Behav Neurol. 2022 Sep 1;35(3):198-203. doi: 10.1097/WNN.0000000000000310.
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief, standardized neuropsychological test that assesses several areas of cognitive function. Recent studies, although sparse, have examined the use of the RBANS to detect cognitive deficits in individuals with manifest Huntington disease (HD); however, no studies have investigated its utility to detect cognitive deficits in individuals with premanifest HD (PreHD), where cognitive symptoms are thought to be more subtle.
To assess cognitive deficits in individuals with HD, particularly in individuals with PreHD, using an easily administered, brief but comprehensive, neuropsychological test.
We administered the RBANS to 31 individuals with HD, 29 individuals with PreHD, and 22 healthy controls (HC) at an academic HD clinical research center and collected RBANS Total, Index, and subtest scores for group comparisons.
The HD group had significantly lower RBANS Total, Index, and subtest scores than the HC. The PreHD group had significantly lower RBANS Total scores and Coding subtest scores than the HC, but no other significant group differences were identified.
Our results substantiate previous findings of significant impairment on the RBANS in individuals with HD. In addition, we are the first to demonstrate that, although the RBANS can identify deficits in psychomotor speed and information processing in individuals with PreHD, it does not appear to have the ability to detect impairment in any additional cognitive domains in individuals with PreHD.
重复认知评估成套测验（RBANS）是一种简短、标准化的认知测试，评估几个认知功能领域。虽然研究较少，但最近的研究已经检查了 RBANS 在检测有明显亨廷顿病（HD）的个体认知缺陷方面的应用；然而，尚无研究探讨其在检测有前显亨廷顿病（PreHD）的个体认知缺陷方面的效用，因为在 PreHD 中，认知症状被认为更为微妙。
使用一种易于管理的简短但全面的认知测试，评估 HD 患者，尤其是 PreHD 患者的认知缺陷。
我们在一个学术性 HD 临床研究中心对 31 名 HD 患者、29 名 PreHD 患者和 22 名健康对照者（HC）进行了 RBANS 测试，并对组间 RBANS 总分、指数和子测试分数进行了比较。
HD 组的 RBANS 总分、指数和子测试分数明显低于 HC 组。PreHD 组的 RBANS 总分和编码子测试分数明显低于 HC 组，但未发现其他显著的组间差异。
我们的结果证实了先前在 HD 患者中 RBANS 显著受损的发现。此外，我们首次证明，尽管 RBANS 可以识别 PreHD 患者的运动速度和信息处理方面的缺陷，但它似乎没有能力在 PreHD 患者的任何其他认知领域中检测到损害。
